| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50467136 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1795011 (CHEMBL4267128) |
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| IC50 | 5.6±n/a nM |
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| Citation |  Choung, W; Jung, HJ; Nam, EH; Yang, D; Yoo, B; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, KH; Chin, J; Jung, K; Lee, G; Kim, SH Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPAR? derived from the AT1R antagonist, Fimasartan. Bioorg Med Chem Lett28:3155-3160 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM50467136 |
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| n/a |
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| Name | BDBM50467136 |
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| Synonyms: | CHEMBL4284022 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N5O4S |
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| Mol. Mass. | 559.679 |
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| SMILES | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1 |
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| Structure | 
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