Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM50467678 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1796588 (CHEMBL4268705) |
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IC50 | 5.6±n/a nM |
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Citation | Liao, G; Yang, D; Ma, L; Li, W; Hu, L; Zeng, L; Wu, P; Duan, L; Liu, Z The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy. Eur J Med Chem159:1-9 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM50467678 |
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n/a |
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Name | BDBM50467678 |
Synonyms: | Ds-3032 | Milademetan |
Type | Small organic molecule |
Emp. Form. | C30H34Cl2FN5O4 |
Mol. Mass. | 618.526 |
SMILES | CC1(C)CCC2(CC1)N[C@H]([C@H](c1ccnc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@@H]1CC[C@H](OC1)C(N)=O |r| |
Structure |
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