| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Ligand | BDBM50470780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157200 (CHEMBL767095) |
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| IC50 | 129±n/a nM |
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| Citation |  Duplantier, AJ; Biggers, MS; Chambers, RJ; Cheng, JB; Cooper, K; Damon, DB; Eggler, JF; Kraus, KG; Marfat, A; Masamune, H; Pillar, JS; Shirley, JT; Umland, JP; Watson, JW Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret. J Med Chem39:120-5 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Synonyms: | DPDE3 | PDE4D_MOUSE | Pde4d |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84520.85 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_105062 |
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| Residue: | 747 |
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| Sequence: | MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQAD
LRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQAN
FVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVS
EMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPM
SQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLT
VIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP
ALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFK
LLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLL
LDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCD
KHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPD
DQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLD
EQVEEEAVAEEESQPETCVPDDCCPDT
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| BDBM50470780 |
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| n/a |
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| Name | BDBM50470780 |
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| Synonyms: | CHEMBL21305 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26O4 |
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| Mol. Mass. | 402.4822 |
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| SMILES | COc1ccc(cc1OC1(CCCc2ccccc2)CC1)-c1ccc(cc1)C(O)=O |
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| Structure | 
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