| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Ligand | BDBM50475597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_328935 (CHEMBL859885) |
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| IC50 | 21200±n/a nM |
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| Citation |  Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett16:176-80 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
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| Synonyms: | MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB |
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| Type: | Protein |
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| Mol. Mass.: | 37848.05 |
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| Organism: | Escherichia coli K-12 (Enterobacteria) |
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| Description: | E. coli MurB |
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| Residue: | 342 |
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| Sequence: | MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
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| BDBM50475597 |
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| n/a |
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| Name | BDBM50475597 |
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| Synonyms: | CHEMBL380752 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16ClF4NO4 |
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| Mol. Mass. | 469.813 |
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| SMILES | OC1=C(C(=O)O\C1=C/c1cc(ccc1Cl)C(F)(F)F)c1ccc(N2CCOCC2)c(F)c1 |t:1| |
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| Structure | 
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