| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramate--L-alanine ligase |
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| Ligand | BDBM50475607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_328936 (CHEMBL859886) |
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| IC50 | 21700±n/a nM |
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| Citation |  Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett16:176-80 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramate--L-alanine ligase |
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| Name: | UDP-N-acetylmuramate--L-alanine ligase |
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| Synonyms: | MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC |
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| Type: | Protein |
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| Mol. Mass.: | 53617.78 |
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| Organism: | Escherichia coli |
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| Description: | P17952 |
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| Residue: | 491 |
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| Sequence: | MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
MNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAA
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
DSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD
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| BDBM50475607 |
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| n/a |
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| Name | BDBM50475607 |
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| Synonyms: | CHEMBL199629 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H13ClF4O3 |
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| Mol. Mass. | 460.805 |
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| SMILES | OC1=C(C(=O)O\C1=C/c1cccc(c1Cl)C(F)(F)F)c1ccc(c(F)c1)-c1ccccc1 |t:1| |
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| Structure | 
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