| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Ligand | BDBM50475591 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_328940 (CHEMBL859890) |
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| IC50 | 12500±n/a nM |
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| Citation |  Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett16:176-80 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Name: | UDP-N-acetylmuramoylalanine--D-glutamate ligase |
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| Synonyms: | MURD_STAAU | MurD (S. aureus) | murD |
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| Type: | Protein |
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| Mol. Mass.: | 49837.61 |
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| Organism: | Staphylococcus aureus (Firmicutes) |
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| Description: | S. aureus MurD |
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| Residue: | 449 |
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| Sequence: | MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVV
SGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTN
GKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKP
HIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLY
FSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIID
SLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFD
ELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSP
ACASWDQYSTFEERGEKFIERFRAHLPSY
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| BDBM50475591 |
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| n/a |
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| Name | BDBM50475591 |
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| Synonyms: | CHEMBL382328 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H12Cl4O3 |
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| Mol. Mass. | 478.152 |
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| SMILES | OC1=C(C(=O)O\C1=C/c1cccc(c1)-c1cc(Cl)cc(Cl)c1)c1cc(Cl)cc(Cl)c1 |t:1| |
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| Structure | 
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