| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM1866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_534522 (CHEMBL984612) |
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| IC50 | 1030±n/a nM |
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| Citation |  Cesarini, S; Spallarossa, A; Ranise, A; Bruno, O; La Colla, P; Secci, B; Collu, G; Loddo, R Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate. Bioorg Med Chem16:4173-85 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM1866 |
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| n/a |
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| Name | BDBM1866 |
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| Synonyms: | 3-(5-bromopyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]thiourea hydrochloride | LY-300046 HCl | LY300046HCl | N-(2-(2-Pyridylethyl))-N -(2-(5-bromopyridyl))thiourea | PETT deriv. | Trovirdine |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13BrN4S |
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| Mol. Mass. | 337.238 |
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| SMILES | Brc1ccc(NC(=S)NCCc2ccccn2)nc1 |
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| Structure | 
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