Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50480059 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_523678 (CHEMBL997193) |
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IC50 | 0.120000±n/a nM |
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Citation | Keown, LE; Collins, I; Cooper, LC; Harrison, T; Madin, A; Mistry, J; Reilly, M; Shaimi, M; Welch, CJ; Clarke, EE; Lewis, HD; Wrigley, JD; Best, JD; Murray, F; Shearman, MS Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity. J Med Chem52:3441-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50480059 |
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n/a |
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Name | BDBM50480059 |
Synonyms: | CHEMBL523883 |
Type | Small organic molecule |
Emp. Form. | C25H23F5N4O2S |
Mol. Mass. | 538.533 |
SMILES | [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(F)c(F)c1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r| |
Structure |
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