Reaction Details |
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Target | Integrase |
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Ligand | BDBM50045107 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_666883 (CHEMBL1262280) |
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Kd | 26±n/a nM |
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Citation | Garvey, EP; Johns, BA; Gartland, MJ; Foster, SA; Miller, WH; Ferris, RG; Hazen, RJ; Underwood, MR; Boros, EE; Thompson, JB; Weatherhead, JG; Koble, CS; Allen, SH; Schaller, LT; Sherrill, RG; Yoshinaga, T; Kobayashi, M; Wakasa-Morimoto, C; Miki, S; Nakahara, K; Noshi, T; Sato, A; Fujiwara, T The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother52:901-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50045107 |
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n/a |
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Name | BDBM50045107 |
Synonyms: | CHEMBL1256978 | GSK364735 |
Type | Small organic molecule |
Emp. Form. | C19H18FN3O4 |
Mol. Mass. | 371.3623 |
SMILES | Cn1c2cc(Cc3ccc(F)cc3)cnc2c(O)c(C(=O)NCCO)c1=O |
Structure |
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