| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50484397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_787739 (CHEMBL1918322) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Johns, BA; Kawasuji, T; Weatherhead, JG; Boros, EE; Thompson, JB; Garvey, EP; Foster, SA; Jeffrey, JL; Miller, WH; Kurose, N; Matsumura, K; Fujiwara, T Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors. Bioorg Med Chem Lett21:6461-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50484397 |
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| n/a |
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| Name | BDBM50484397 |
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| Synonyms: | CHEMBL1914460 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24F2N4O4 |
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| Mol. Mass. | 506.5007 |
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| SMILES | CN(C)C(=O)Cn1c2cc(Cc3ccc(F)cc3)cnc2c(O)c(C(=O)NCc2ccc(F)cc2)c1=O |
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| Structure | 
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