Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50485007 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_814406 (CHEMBL2019730) |
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IC50 | 70±n/a nM |
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Citation | Close, J; Heidebrecht, R; Hendrix, J; Li, C; Munoz, B; Surdi, L; Kattar, S; Tempest, P; Moses, P; Geng, X; Hughes, B; Smotrov, N; Moxham, C; Chapnick, J; Kariv, I; Nikov, G; Burke, JE; Deshmukh, S; Jeliazkova-Mecheva, V; Leach, JK; Diaz, D; Xu, L; Yang, Z; Kwei, G; Moy, L; Shah, S; Tanga, F; Kenefic, C; Savage, D; Shearman, M; Ball, RG; McNevin, MJ; Markarewicz, A; Miller, T Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors. Bioorg Med Chem Lett22:3203-7 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50485007 |
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n/a |
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Name | BDBM50485007 |
Synonyms: | CHEMBL2019001 |
Type | Small organic molecule |
Emp. Form. | C28H25ClF2N2O4S |
Mol. Mass. | 559.024 |
SMILES | COc1ccc2c(cn(C)c2c1)C(=O)N1CCC(CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1 |
Structure |
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