| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50485192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_822365 (CHEMBL2038743) |
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| IC50 | 450±n/a nM |
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| Citation |  Gu, SX; Li, ZM; Ma, XD; Yang, SQ; He, QQ; Chen, FE; De Clercq, E; Balzarini, J; Pannecouque, C Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem53:229-34 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50485192 |
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| n/a |
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| Name | BDBM50485192 |
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| Synonyms: | CHEMBL1817673 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13ClN4O |
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| Mol. Mass. | 336.775 |
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| SMILES | OC(c1ccnc(Nc2ccc(cc2)C#N)n1)c1ccccc1Cl |
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| Structure | 
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