| Reaction Details |
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 | Report a problem with these data |
| Target | Elastase |
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| Ligand | BDBM50485652 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_850302 (CHEMBL2150722) |
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| IC50 | 220000±n/a nM |
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| Citation |  Garner, AL; Struss, AK; Fullagar, JL; Agrawal, A; Moreno, AY; Cohen, SM; Janda, KD 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. ACS Med Chem Lett3:668-672 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Elastase |
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| Name: | Elastase |
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| Synonyms: | ELAS_PSEAE | Pseudolysin | lasB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53687.94 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_619859 |
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| Residue: | 498 |
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| Sequence: | MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKA
IRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTT
AAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFV
IDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMN
SSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMK
VHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMN
EAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVH
HSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSA
ADVTRAFSTVGVTCPSAL
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| BDBM50485652 |
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| n/a |
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| Name | BDBM50485652 |
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| Synonyms: | CHEMBL1650621 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H7NOS |
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| Mol. Mass. | 141.191 |
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| SMILES | Cn1cccc(O)c1=S |
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| Structure | 
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