Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50485806 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_858067 (CHEMBL2166979) |
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IC50 | 0.190000±n/a nM |
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Citation | Parker, MF; Barten, DM; Bergstrom, CP; Bronson, JJ; Corsa, JA; Dee, MF; Gai, Y; Guss, VL; Higgins, MA; Keavy, DJ; Loo, A; Mate, RA; Marcin, LR; McElhone, KE; Polson, CT; Roberts, SB; Macor, JE 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors. Bioorg Med Chem Lett22:6828-31 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50485806 |
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n/a |
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Name | BDBM50485806 |
Synonyms: | CHEMBL2164125 |
Type | Small organic molecule |
Emp. Form. | C20H25ClN2O4S |
Mol. Mass. | 424.941 |
SMILES | COc1ccc(CN([C@H](CC(C)C)C(N)=O)S(=O)(=O)c2ccc(Cl)cc2)cc1 |r| |
Structure |
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