Reaction Details | |||
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Target | Substance-P receptor | ||
Ligand | BDBM50030232 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_143026 (CHEMBL857542) | ||
IC50 | 0.48±n/a nM | ||
Citation | Lowe, JA; Drozda, SE; McLean, S; Bryce, DK; Crawford, RT; Snider, RM; Longo, KP; Nagahisa, A; Tsuchiya, M Aza-tricyclic substance P antagonists. J Med Chem37:2831-40 (1994) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Substance-P receptor | |||
Name: | Substance-P receptor | ||
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 46254.43 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P25103 | ||
Residue: | 407 | ||
Sequence: |
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BDBM50030232 | |||
n/a | |||
Name | BDBM50030232 | ||
Synonyms: | (S)-((S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-(2-methoxy-benzyl)-amine | CHEMBL95638 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H32N2O | ||
Mol. Mass. | 412.5665 | ||
SMILES | COc1ccccc1CNC1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 |wD:17.20,(7.71,-5.53,;6.37,-4.76,;6.37,-3.22,;7.71,-2.45,;7.71,-.89,;6.37,-.12,;5.04,-.91,;5.04,-2.45,;3.69,-3.22,;3.69,-4.76,;2.36,-5.53,;1.03,-4.74,;-.3,-5.51,;-.3,-7.05,;1.07,-7.8,;.31,-6.47,;1.8,-6.07,;2.36,-7.07,;3.71,-7.82,;3.69,-9.38,;2.36,-10.13,;2.36,-11.67,;3.69,-12.44,;5.04,-11.67,;5.02,-10.13,;5.19,-7.43,;6.28,-8.52,;7.77,-8.1,;8.15,-6.63,;7.05,-5.54,;5.58,-5.95,)| | ||
Structure |