| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50030241 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_143026 (CHEMBL857542) |
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| IC50 | 4.1±n/a nM |
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| Citation |  Lowe, JA; Drozda, SE; McLean, S; Bryce, DK; Crawford, RT; Snider, RM; Longo, KP; Nagahisa, A; Tsuchiya, M Aza-tricyclic substance P antagonists. J Med Chem37:2831-40 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50030241 |
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| n/a |
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| Name | BDBM50030241 |
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| Synonyms: | (S)-((S)-9-Benzhydryl-8-aza-tricyclo[5.3.1.0*3,8*]undec-10-yl)-(2-methoxy-benzyl)-amine | CHEMBL442962 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H36N2O |
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| Mol. Mass. | 452.6303 |
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| SMILES | COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 |TLB:14:13:20.10:17.18| |
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| Structure | 
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