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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | High affinity nerve growth factor receptor | ||
| Ligand | BDBM50224533 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2263728 | ||
| IC50 | 1.1±n/a nM | ||
| Citation |  Sun, M; Cai, S; Li, P; Zhang, F; Zhang, H; Zhou, J Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| High affinity nerve growth factor receptor | |||
| Name: | High affinity nerve growth factor receptor | ||
| Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA | ||
| Type: | n/a | ||
| Mol. Mass.: | 87498.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04629 | ||
| Residue: | 796 | ||
| Sequence: |
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| BDBM50224533 | |||
| n/a | |||
| Name | BDBM50224533 | ||
| Synonyms: | CHEMBL5266269 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26FN5O2 | ||
| Mol. Mass. | 411.4725 | ||
| SMILES | CO[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N(C)Cc1cccc(F)c1 |r,wU:5.8,wD:2.1,(8.78,3.29,;9.18,1.81,;8.09,.72,;6.6,1.11,;5.52,.03,;5.91,-1.46,;7.4,-1.86,;8.49,-.77,;4.83,-2.55,;3.34,-2.15,;2.25,-3.24,;2.94,-.66,;3.85,.58,;2.97,1.79,;1.48,1.32,;.15,2.09,;-1.18,1.33,;-1.18,-.21,;.16,-.99,;1.48,-.21,;-2.52,-.98,;-2.52,-2.52,;-3.85,-.21,;-5.19,-.98,;-5.19,-2.52,;-6.51,-3.29,;-7.85,-2.53,;-7.85,-.99,;-9.18,-.22,;-6.51,-.22,)| | ||
| Structure | 
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