| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50493206 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_978401 (CHEMBL2421043) |
|---|
| IC50 | >20000±n/a nM |
|---|
| Citation |  Serrao, E; Xu, ZL; Debnath, B; Christ, F; Debyser, Z; Long, YQ; Neamati, N Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction. Bioorg Med Chem21:5963-72 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | pol |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32203.43 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_106649 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50493206 |
|---|
| n/a |
|---|
| Name | BDBM50493206 |
|---|
| Synonyms: | CHEMBL1703922 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H8FN3O3 |
|---|
| Mol. Mass. | 249.1979 |
|---|
| SMILES | OC(=O)c1[nH]cnc1C(=O)Nc1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
