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TargetGlycogen synthase kinase-3 beta
LigandBDBM50494526
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1277811 (CHEMBL3097577)
IC50 1800±n/a nM
Citation Uehara, F; Shoda, A; Aritomo, K; Fukunaga, K; Watanabe, K; Ando, R; Shinoda, M; Ueno, H; Kubodera, H; Sunada, S; Saito, K; Kaji, T; Asano, S; Eguchi, J; Yuki, S; Tanaka, S; Yoneyama, Y; Niwa, T 6-(4-Pyridyl)pyrimidin-4(3H)-ones as CNS penetrant glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett23:6928-32 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50494526
n/a
NameBDBM50494526
Synonyms:CHEMBL3093039
TypeSmall organic molecule
Emp. Form.C15H11N3O
Mol. Mass.249.2673
SMILESO=c1cc(nc([nH]1)-c1ccccc1)-c1ccncc1
Structure
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