Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50494533 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1277811 (CHEMBL3097577) |
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IC50 | 70±n/a nM |
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Citation | Uehara, F; Shoda, A; Aritomo, K; Fukunaga, K; Watanabe, K; Ando, R; Shinoda, M; Ueno, H; Kubodera, H; Sunada, S; Saito, K; Kaji, T; Asano, S; Eguchi, J; Yuki, S; Tanaka, S; Yoneyama, Y; Niwa, T 6-(4-Pyridyl)pyrimidin-4(3H)-ones as CNS penetrant glycogen synthase kinase-3? inhibitors. Bioorg Med Chem Lett23:6928-32 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50494533 |
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n/a |
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Name | BDBM50494533 |
Synonyms: | CHEMBL3093048 |
Type | Small organic molecule |
Emp. Form. | C18H18N4O |
Mol. Mass. | 306.3617 |
SMILES | Cn1c(NCCc2ccccc2)nc(cc1=O)-c1ccncc1 |
Structure |
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