Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M2 | ||
| Ligand | BDBM50497838 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1455704 (CHEMBL3366379) | ||
| Ki | 18±n/a nM | ||
| Citation |  Schmitz, J; van der Mey, D; Bermudez, M; Klöckner, J; Schrage, R; Kostenis, E; Tränkle, C; Wolber, G; Mohr, K; Holzgrabe, U Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity. J Med Chem57:6739-50 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M2 | |||
| Name: | Muscarinic acetylcholine receptor M2 | ||
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 | ||
| Type: | GPCR | ||
| Mol. Mass.: | 51730.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08172 | ||
| Residue: | 466 | ||
| Sequence: |
| ||
| BDBM50497838 | |||
| n/a | |||
| Name | BDBM50497838 | ||
| Synonyms: | CHEMBL3323279 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H44Br2N2O3 | ||
| Mol. Mass. | 592.447 | ||
| SMILES | [Br-].[Br-].[H][C@@]12CC[C@]([H])(C[C@H](C1)OC(=O)C(CO)c1ccccc1)[N+]2(C)CCCCCC[N+](C)(C)C |r,wD:9.9,3.0,6.4,TLB:25:23:9.10.8:4.5,11:9:23:4.5,(37.24,-11.04,;32.43,-8.67,;34.06,-16.83,;33.99,-14.97,;32.61,-15.71,;32.31,-17.23,;33.35,-16.49,;33.95,-18.26,;34.83,-16.43,;35.88,-17.19,;35.49,-15.65,;35.88,-18.74,;37.2,-19.47,;37.2,-20.99,;38.51,-18.71,;38.51,-17.19,;39.85,-16.45,;39.85,-19.47,;41.16,-18.71,;42.48,-19.47,;42.48,-20.99,;41.16,-21.76,;39.85,-20.99,;32.84,-13.8,;32.13,-12.46,;31.27,-13.8,;30.49,-12.44,;28.92,-12.44,;28.13,-11.08,;26.56,-11.08,;25.78,-9.73,;24.21,-9.73,;23.43,-8.37,;23.43,-11.08,;22.63,-9.71,)| | ||
| Structure | 
| ||