| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50502493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1807706 (CHEMBL4307065) |
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| IC50 | 0.003±n/a nM |
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| Citation |  Kargbo, RB Treatment of Cancers by Inhibition of Isoprenylcysteine Carboxyl Methyltransferase. ACS Med Chem Lett10:1024-1025 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50502493 |
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| n/a |
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| Name | BDBM50502493 |
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| Synonyms: | CHEMBL4558383 | US11834430, Compound 81 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3O3 |
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| Mol. Mass. | 389.447 |
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| SMILES | COc1cc(ccc1O[C@@H](C)COc1cccc(c1)-n1ccnc1C1CC1)C#N |r| |
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| Structure | 
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