| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50503102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809399 (CHEMBL4308758) |
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| IC50 | 260±n/a nM |
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| Citation |  O'Malley, DP; Ahuja, V; Fink, B; Cao, C; Wang, C; Swanson, J; Wee, S; Gavai, AV; Tokarski, J; Critton, D; Paiva, AA; Johnson, BM; Szapiel, N; Xie, D Discovery of Pyridazinone and Pyrazolo[1,5- ACS Med Chem Lett10:1486-1491 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50503102 |
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| n/a |
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| Name | BDBM50503102 |
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| Synonyms: | CHEMBL4445994 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H32ClFN8O4 |
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| Mol. Mass. | 671.12 |
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| SMILES | COc1ccc2c(cnn2c1)C(=O)Nc1ccc(NC(=O)c2nn(C3CCN(CC3)C(=O)CC(C)(C)C#N)c3ccc(F)cc23)cc1Cl |
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| Structure | 
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