| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50503977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812820 (CHEMBL4312394) |
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| IC50 | >300±n/a nM |
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| Citation |  Wu, H; Yang, K; Zhang, Z; Leisten, ED; Li, Z; Xie, H; Liu, J; Smith, KA; Novakova, Z; Barinka, C; Tang, W Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity. J Med Chem62:7042-7057 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50503977 |
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| n/a |
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| Name | BDBM50503977 |
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| Synonyms: | CHEMBL4465902 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H45N9O8 |
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| Mol. Mass. | 779.8408 |
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| SMILES | CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccc(OCCCCCn2cc(CNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)nn2)cc1 |
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| Structure | 
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