Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Receptor-interacting serine/threonine-protein kinase 2 |
---|
Ligand | BDBM50504978 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1816947 (CHEMBL4316521) |
---|
IC50 | 50±n/a nM |
---|
Citation | Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, H; Lian, Y; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, H; Bertin, J; Marquis, RW Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors. ACS Med Chem Lett10:1518-1523 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Receptor-interacting serine/threonine-protein kinase 2 |
---|
Name: | Receptor-interacting serine/threonine-protein kinase 2 |
Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
Type: | Protein |
Mol. Mass.: | 61201.30 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 540 |
Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
|
|
|
BDBM50504978 |
---|
n/a |
---|
Name | BDBM50504978 |
Synonyms: | CHEMBL4527824 |
Type | Small organic molecule |
Emp. Form. | C17H17N5O2S |
Mol. Mass. | 355.414 |
SMILES | [H][C@]12C[C@H](O)[C@]([H])(C1)Nc1c(C(N)=O)c(nn1C2)-c1ccc2scnc2c1 |r| |
Structure |
|