Reaction Details |
| Report a problem with these data |
Target | Epidermal growth factor receptor |
---|
Ligand | BDBM50505840 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1824360 (CHEMBL4324124) |
---|
IC50 | 2300±n/a nM |
---|
Citation | Engelhardt, H; Böse, D; Petronczki, M; Scharn, D; Bader, G; Baum, A; Bergner, A; Chong, E; Döbel, S; Egger, G; Engelhardt, C; Ettmayer, P; Fuchs, JE; Gerstberger, T; Gonnella, N; Grimm, A; Grondal, E; Haddad, N; Hopfgartner, B; Kousek, R; Krawiec, M; Kriz, M; Lamarre, L; Leung, J; Mayer, M; Patel, ND; Simov, BP; Reeves, JT; Schnitzer, R; Schrenk, A; Sharps, B; Solca, F; Stadtmüller, H; Tan, Z; Wunberg, T; Zoephel, A; McConnell, DB Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors. J Med Chem62:10272-10293 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Epidermal growth factor receptor |
---|
Name: | Epidermal growth factor receptor |
Synonyms: | EGFR_MOUSE | Egfr | Epidermal growth factor receptor erbB1 |
Type: | PROTEIN |
Mol. Mass.: | 134859.02 |
Organism: | Mus musculus |
Description: | ChEMBL_305656 |
Residue: | 1210 |
Sequence: | MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALA
ILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDL
QSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGC
TGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFK
YCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKL
FGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCN
ILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIM
GENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIV
VVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVL
GSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLL
GICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDL
AARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVW
SYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR
PKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLI
PQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTED
NIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLN
TAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRV
APPSSEFIGA
|
|
|
BDBM50505840 |
---|
n/a |
---|
Name | BDBM50505840 |
Synonyms: | CHEMBL4550104 |
Type | Small organic molecule |
Emp. Form. | C23H24N6O2 |
Mol. Mass. | 416.4757 |
SMILES | Cc1cc2cc(n1)-c1cnn(C)c1OCCCCCN1\C(Nc3ccccc13)=N\C2=O |t:31| |
Structure |
|