| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein Mdm4 |
|---|
| Ligand | BDBM50506488 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1825984 (CHEMBL4325748) |
|---|
| IC50 | 6600±n/a nM |
|---|
| Citation |  Sang, P; Shi, Y; Lu, J; Chen, L; Yang, L; Borcherds, W; Abdulkadir, S; Li, Q; Daughdrill, G; Chen, J; Cai, J ?-Helix-Mimicking Sulfono-?-AApeptide Inhibitors for p53-MDM2/MDMX Protein-Protein Interactions. J Med Chem63:975-986 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein Mdm4 |
|---|
| Name: | Protein Mdm4 |
|---|
| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 54842.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
|---|
| Residue: | 490 |
|---|
| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
|
|
|
|---|
| BDBM50506488 |
|---|
| n/a |
|---|
| Name | BDBM50506488 |
|---|
| Synonyms: | CHEMBL4474794 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C83H134ClN17O24S7 |
|---|
| Mol. Mass. | 2013.96 |
|---|
| SMILES | CC(C)C[C@@H](CN(CC(=O)N[C@H](CN(CC(=O)N[C@@H](CCC(O)=O)CN1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(=O)(=O)CC\C=C\CCCCS1(=O)=O)S(C)(=O)=O)S(C)(=O)=O)Cc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1)NC(C)=O |r,t:96| |
|---|
| Structure | 
|
|---|
Search and Browse
