| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP], mitochondrial |
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| Ligand | BDBM50508243 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1832266 (CHEMBL4332274) |
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| IC50 | >20000±n/a nM |
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| Citation |  Liu, X; Hu, Y; Gao, A; Xu, M; Gao, L; Xu, L; Zhou, Y; Gao, J; Ye, Q; Li, J Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors. Bioorg Med Chem27:589-603 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP], mitochondrial |
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| Name: | Isocitrate dehydrogenase [NADP], mitochondrial |
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| Synonyms: | IDH2 | IDH2 (R172K, 40-end) | IDHP_HUMAN | Isocitrate dehydrogenase 2 (IDH2) |
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| Type: | Protein |
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| Mol. Mass.: | 50923.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length wild-type |
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| Residue: | 452 |
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| Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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| BDBM50508243 |
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| n/a |
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| Name | BDBM50508243 |
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| Synonyms: | CHEMBL4514241 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20ClN7O2 |
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| Mol. Mass. | 485.925 |
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| SMILES | Cn1nc(C2=C(C(=O)NC2=O)c2cn(CCCn3ccnc3)c3cc(Cl)ccc23)c2cccnc12 |t:4| |
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| Structure | 
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