Reaction Details |
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Target | Isocitrate dehydrogenase [NADP], mitochondrial |
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Ligand | BDBM50508253 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1832266 (CHEMBL4332274) |
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IC50 | >20000±n/a nM |
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Citation | Liu, X; Hu, Y; Gao, A; Xu, M; Gao, L; Xu, L; Zhou, Y; Gao, J; Ye, Q; Li, J Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors. Bioorg Med Chem27:589-603 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP], mitochondrial |
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Name: | Isocitrate dehydrogenase [NADP], mitochondrial |
Synonyms: | IDH2 | IDH2 (R172K, 40-end) | IDHP_HUMAN | Isocitrate dehydrogenase 2 (IDH2) |
Type: | Protein |
Mol. Mass.: | 50923.31 |
Organism: | Homo sapiens (Human) |
Description: | Full-length wild-type |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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BDBM50508253 |
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n/a |
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Name | BDBM50508253 |
Synonyms: | CHEMBL4469450 |
Type | Small organic molecule |
Emp. Form. | C26H23N7O2 |
Mol. Mass. | 465.5065 |
SMILES | Cn1nc(C2=C(C(=O)NC2=O)c2cn(CCCCn3ccnc3)c3ccccc23)c2cccnc12 |t:4| |
Structure |
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