Reaction Details |
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Target | Gastrin/cholecystokinin type B receptor |
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Ligand | BDBM50061214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_47829 (CHEMBL662571) |
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IC50 | >1000±n/a nM |
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Citation | Selnick, HG; Liverton, NJ; Baldwin, JJ; Butcher, JW; Claremon, DA; Elliott, JM; Freidinger, RM; King, SA; Libby, BE; McIntyre, CJ; Pribush, DA; Remy, DC; Smith, GR; Tebben, AJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Sanguinetti, MC; Siegl, PK; Slaughter, DE; Vyas, K Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. J Med Chem40:3865-8 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gastrin/cholecystokinin type B receptor |
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Name: | Gastrin/cholecystokinin type B receptor |
Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48445.79 |
Organism: | Homo sapiens (Human) |
Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
Residue: | 447 |
Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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BDBM50061214 |
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n/a |
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Name | BDBM50061214 |
Synonyms: | 3-(4-Amino-phenyl)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide | CHEMBL420516 |
Type | Small organic molecule |
Emp. Form. | C25H24N4O2 |
Mol. Mass. | 412.4837 |
SMILES | CN1c2ccccc2C(=N[C@@H](NC(=O)CCc2ccc(N)cc2)C1=O)c1ccccc1 |c:9| |
Structure |
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