| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50064337 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72361 (CHEMBL686598) |
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| IC50 | 124±n/a nM |
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| Citation |  García-Echeverría, C; Furet, P; Gay, B; Fretz, H; Rahuel, J; Schoepfer, J; Caravatti, G Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2. J Med Chem41:1741-4 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50064337 |
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| n/a |
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| Name | BDBM50064337 |
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| Synonyms: | CHEMBL2372814 | Phosphoric acid mono-(2-amino-4-{2-amino-2-[1-(1,2-dicarbamoyl-ethylcarbamoyl)-cyclopropylcarbamoyl]-ethyl}-phenyl) ester |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25N6O8P |
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| Mol. Mass. | 472.3896 |
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| SMILES | N[C@@H](Cc1ccc(OP(O)(O)=O)c(N)c1)C(=O)NC1(CC1)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| |
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| Structure | 
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