| Reaction Details |
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 | Report a problem with these data |
| Target | Glucocorticoid receptor |
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| Ligand | BDBM50510667 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1841970 (CHEMBL4342269) |
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| IC50 | 202±n/a nM |
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| Citation |  Liu, K; Kurukulasuriya, R; Dykstra, K; DiMichelle, L; Liu, J; Vachal, P; Ogawa, A; DeVita, RJ; Shen, DM; Tan, Q; Chen, Y; Gauthier, D; Verras, A; Crespo, A; Zamlynny, B; Madwed, J; Hoek, M; Bateman, T; Yang, YF; Houk, KN; Krska, S; Cernak, T Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization. Bioorg Med Chem Lett29:1854-1858 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucocorticoid receptor |
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| Name: | Glucocorticoid receptor |
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| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85656.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04150 |
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| Residue: | 777 |
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| Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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| BDBM50510667 |
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| n/a |
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| Name | BDBM50510667 |
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| Synonyms: | CHEMBL4515343 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20BrClN2O3S |
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| Mol. Mass. | 471.796 |
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| SMILES | CCC(CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cc(Br)cc12 |
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| Structure | 
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