| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
|---|
| Ligand | BDBM50510660 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1841953 (CHEMBL4342252) |
|---|
| IC50 | 32±n/a nM |
|---|
| Citation |  Liu, K; Kurukulasuriya, R; Dykstra, K; DiMichelle, L; Liu, J; Vachal, P; Ogawa, A; DeVita, RJ; Shen, DM; Tan, Q; Chen, Y; Gauthier, D; Verras, A; Crespo, A; Zamlynny, B; Madwed, J; Hoek, M; Bateman, T; Yang, YF; Houk, KN; Krska, S; Cernak, T Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization. Bioorg Med Chem Lett29:1854-1858 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mineralocorticoid receptor |
|---|
| Name: | Mineralocorticoid receptor |
|---|
| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 107076.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08235 |
|---|
| Residue: | 984 |
|---|
| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
|
|
|
|---|
| BDBM50510660 |
|---|
| n/a |
|---|
| Name | BDBM50510660 |
|---|
| Synonyms: | CHEMBL4578762 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20ClFN2O3S |
|---|
| Mol. Mass. | 410.89 |
|---|
| SMILES | CC[C@](CO)(c1ccc(Cl)cc1)n1ccc2c(NS(C)(=O)=O)cc(F)cc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
