| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50454946 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28347 (CHEMBL643358) |
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| IC50 | 12±n/a nM |
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| Citation |  Tanaka, A; Terasawa, T; Hagihara, H; Sakuma, Y; Ishibe, N; Sawada, M; Takasugi, H; Tanaka, H Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. J Med Chem41:2390-410 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Acyl-CoA:cholesterol acyltransferase |
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| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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| BDBM50454946 |
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| n/a |
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| Name | BDBM50454946 |
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| Synonyms: | CHEMBL79602 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24F3N5O |
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| Mol. Mass. | 479.4969 |
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| SMILES | CN(C)c1ccc(CN(Cc2cccc(c2)-c2cc[nH]n2)C(=O)Nc2c(F)cc(F)cc2F)cc1 |
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| Structure | 
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