| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50067049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40704 (CHEMBL654916) |
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| IC50 | 511.0±n/a nM |
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| Citation |  Heinze-Krauss, I; Angehrn, P; Charnas, RL; Gubernator, K; Gutknecht, EM; Hubschwerlen, C; Kania, M; Oefner, C; Page, MG; Sogabe, S; Specklin, JL; Winkler, F Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams. J Med Chem41:3961-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
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| Type: | Protien |
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| Mol. Mass.: | 41561.62 |
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| Organism: | Escherichia coli |
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| Description: | P00811 |
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| Residue: | 377 |
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| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
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| BDBM50067049 |
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| n/a |
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| Name | BDBM50067049 |
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| Synonyms: | CHEMBL340351 | Sodium; (1S,4S,5S)-2-benzyloxycarbonyl-4-fluoro-7-oxo-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonate |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12FN2O6S |
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| Mol. Mass. | 343.308 |
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| SMILES | [O-]S(=O)(=O)N1[C@H]2[C@H](N(C[C@@H]2F)C(=O)OCc2ccccc2)C1=O |
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| Structure | 
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