Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM50067066 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_41020 (CHEMBL884132) |
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IC50 | 613±n/a nM |
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Citation | Heinze-Krauss, I; Angehrn, P; Charnas, RL; Gubernator, K; Gutknecht, EM; Hubschwerlen, C; Kania, M; Oefner, C; Page, MG; Sogabe, S; Specklin, JL; Winkler, F Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams. J Med Chem41:3961-71 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
Type: | Enzyme |
Mol. Mass.: | 43406.87 |
Organism: | Pseudomonas aeruginosa (PAO1) |
Description: | P24735 |
Residue: | 397 |
Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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BDBM50067066 |
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n/a |
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Name | BDBM50067066 |
Synonyms: | CHEMBL340707 | Sodium; (1S,4R,5S)-2-benzyloxycarbonyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-7-oxo-2,6-diaza-bicyclo[3.2.0]heptane-6-sulfonate |
Type | Small organic molecule |
Emp. Form. | C15H15N6O6S2 |
Mol. Mass. | 439.447 |
SMILES | Cn1nnnc1S[C@@H]1CN([C@H]2[C@@H]1N(C2=O)S([O-])(=O)=O)C(=O)OCc1ccccc1 |
Structure |
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