Ki Summary

Reaction Details

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Target

Protein Mdm4

Ligand

BDBM50513200

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1852377 (CHEMBL4353001)

IC50

2.1±n/a nM

Citation

Liu, Y; Wang, X; Wang, G; Yang, Y; Yuan, Y; Ouyang, L The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. Eur J Med Chem176:92-104 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Protein Mdm4

Name:

Protein Mdm4

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

54842.04

Organism:

Homo sapiens (Human)

Description:

The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.

Residue:

490

Sequence:

MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA

BDBM50513200

n/a

Name

BDBM50513200

Synonyms:

CHEMBL4514512

Type

Small organic molecule

Emp. Form.

C38H48N4O4

Mol. Mass.

624.8121

SMILES

COc1cc2CC(=O)N([C@@H](c3ccccc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1 |r,wU:32.35,wD:9.9,35.42,(19.45,-7.98,;18.11,-7.22,;16.78,-7.99,;15.45,-7.23,;14.13,-8,;12.8,-7.22,;11.47,-8,;10.14,-7.23,;11.47,-9.54,;12.8,-10.3,;12.8,-11.83,;11.47,-12.61,;11.47,-14.14,;12.8,-14.91,;14.14,-14.13,;14.13,-12.6,;14.13,-9.53,;15.46,-10.3,;16.79,-9.53,;18.12,-10.3,;18.12,-11.84,;19.46,-12.61,;16.79,-12.61,;10.14,-10.31,;8.81,-9.54,;7.47,-10.31,;7.48,-11.85,;8.82,-12.62,;10.15,-11.84,;6.14,-12.62,;6.15,-14.16,;4.81,-11.86,;4.8,-10.32,;3.46,-9.55,;3.47,-8.01,;4.8,-7.24,;6.13,-8.01,;6.13,-9.55,;4.8,-5.69,;3.47,-4.93,;3.48,-3.38,;4.82,-2.62,;4.83,-1.08,;6.15,-3.39,;7.48,-2.63,;6.14,-4.93,)|

Structure