Reaction Details |
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Target | Cysteinyl leukotriene receptor 1/2 |
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Ligand | BDBM50216211 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_99858 (CHEMBL706928) |
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IC50 | 0.500000±n/a nM |
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Citation | Guay, D; Gauthier, JY; Dufresne, C; Jones, TR; McAuliffe, M; McFarlane, C; Metters, KM; Prasit, P; Rochette, C; Roy, P; Sawyer, N; Zamboni, R A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair. Bioorg Med Chem Lett8:453-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cysteinyl leukotriene receptor 1/2 |
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Name: | Cysteinyl leukotriene receptor 1/2 |
Synonyms: | Cysteinyl leukotriene receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 98640 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cysteinyl leukotriene receptor 1 |
Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38565.16 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
Residue: | 337 |
Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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Component 2 |
Name: | Cysteinyl leukotriene receptor 2 |
Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39657.52 |
Organism: | Homo sapiens (Human) |
Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
Residue: | 346 |
Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
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BDBM50216211 |
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n/a |
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Name | BDBM50216211 |
Synonyms: | CHEMBL143597 |
Type | Small organic molecule |
Emp. Form. | C35H43NO3S |
Mol. Mass. | 557.786 |
SMILES | CCCc1nc(\C=C\c2cccc(c2)[C@@H](CCc2ccccc2C(C)(C)O)SCC2(CC(O)=O)CC2)ccc1C |
Structure |
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