| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 8 |
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| Ligand | BDBM50514137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855695 (CHEMBL4356424) |
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| IC50 | 1110±n/a nM |
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| Citation |  Padilla-Salinas, R; Anderson, R; Sakaniwa, K; Zhang, S; Nordeen, P; Lu, C; Shimizu, T; Yin, H Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors J Med Chem62:10221-10244 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 8 |
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| Name: | Toll-like receptor 8 |
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| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119828.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR97 |
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| Residue: | 1041 |
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| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
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| BDBM50514137 |
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| n/a |
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| Name | BDBM50514137 |
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| Synonyms: | CHEMBL4455524 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H11ClF7NO2 |
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| Mol. Mass. | 477.759 |
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| SMILES | Fc1ccc(Cl)cc1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 |
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| Structure | 
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