| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxyhypusine synthase |
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| Ligand | BDBM50514710 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858216 (CHEMBL4358945) |
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| IC50 | 62±n/a nM |
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| Citation |  Tanaka, Y; Kurasawa, O; Yokota, A; Klein, MG; Ono, K; Saito, B; Matsumoto, S; Okaniwa, M; Ambrus-Aikelin, G; Morishita, D; Kitazawa, S; Uchiyama, N; Ogawa, K; Kimura, H; Imamura, S Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase. J Med Chem63:3215-3226 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxyhypusine synthase |
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| Name: | Deoxyhypusine synthase |
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| Synonyms: | 2.5.1.46 | DHPS | DHS | DHYS_HUMAN | DS | Deoxyhypusine synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40962.06 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_18047 |
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| Residue: | 369 |
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| Sequence: | MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
AFMHEKNED
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| BDBM50514710 |
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| n/a |
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| Name | BDBM50514710 |
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| Synonyms: | CHEMBL4555677 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11BrN2OS |
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| Mol. Mass. | 371.251 |
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| SMILES | Brc1ccc2cc(sc2c1)C(=O)Nc1cccc2[nH]ccc12 |
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| Structure | 
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