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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Toll-like receptor 8 | ||
| Ligand | BDBM50514795 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1858564 (CHEMBL4359293) | ||
| IC50 | 10120±n/a nM | ||
| Citation |  Jiang, S; Tanji, H; Yin, K; Zhang, S; Sakaniwa, K; Huang, J; Yang, Y; Li, J; Ohto, U; Shimizu, T; Yin, H Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J Med Chem63:4117-4132 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Toll-like receptor 8 | |||
| Name: | Toll-like receptor 8 | ||
| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 119828.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NR97 | ||
| Residue: | 1041 | ||
| Sequence: |
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| BDBM50514795 | |||
| n/a | |||
| Name | BDBM50514795 | ||
| Synonyms: | CHEMBL4475464 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C14H17Cl2N3OS | ||
| Mol. Mass. | 346.275 | ||
| SMILES | CC(C)Sc1nnc(CCCO)n1-c1ccc(Cl)cc1Cl |(27.07,-36.52,;27.97,-35.27,;29.51,-35.44,;27.35,-33.87,;28.25,-32.62,;29.79,-32.62,;30.27,-31.16,;29.02,-30.25,;29.02,-28.71,;30.36,-27.94,;31.69,-28.71,;33.02,-27.94,;27.78,-31.16,;26.31,-30.68,;25.17,-31.71,;23.7,-31.24,;23.38,-29.73,;21.92,-29.25,;24.53,-28.7,;25.99,-29.17,;27.14,-28.14,)| | ||
| Structure | 
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