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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Toll-like receptor 8 | ||
| Ligand | BDBM50514800 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1858564 (CHEMBL4359293) | ||
| IC50 | 630±n/a nM | ||
| Citation |  Jiang, S; Tanji, H; Yin, K; Zhang, S; Sakaniwa, K; Huang, J; Yang, Y; Li, J; Ohto, U; Shimizu, T; Yin, H Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J Med Chem63:4117-4132 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Toll-like receptor 8 | |||
| Name: | Toll-like receptor 8 | ||
| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 119828.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NR97 | ||
| Residue: | 1041 | ||
| Sequence: |
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| BDBM50514800 | |||
| n/a | |||
| Name | BDBM50514800 | ||
| Synonyms: | CHEMBL4449343 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C12H13Cl2N3S | ||
| Mol. Mass. | 302.223 | ||
| SMILES | CCCc1nnc(SC)n1-c1ccc(Cl)cc1Cl |(5.01,-12.3,;6.49,-11.89,;6.89,-10.4,;8.38,-9.99,;8.92,-8.56,;10.43,-8.62,;10.85,-10.1,;12.29,-10.62,;13.46,-9.64,;9.57,-10.95,;9.57,-12.49,;8.24,-13.26,;8.23,-14.8,;9.57,-15.57,;9.57,-17.1,;10.89,-14.8,;10.9,-13.26,;12.24,-12.48,)| | ||
| Structure | 
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