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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Toll-like receptor 8 | ||
| Ligand | BDBM50514816 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1858564 (CHEMBL4359293) | ||
| IC50 | 600±n/a nM | ||
| Citation |  Jiang, S; Tanji, H; Yin, K; Zhang, S; Sakaniwa, K; Huang, J; Yang, Y; Li, J; Ohto, U; Shimizu, T; Yin, H Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J Med Chem63:4117-4132 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Toll-like receptor 8 | |||
| Name: | Toll-like receptor 8 | ||
| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 119828.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NR97 | ||
| Residue: | 1041 | ||
| Sequence: |
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| BDBM50514816 | |||
| n/a | |||
| Name | BDBM50514816 | ||
| Synonyms: | CHEMBL4468868 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C12H12Cl3N3OS | ||
| Mol. Mass. | 352.667 | ||
| SMILES | CSc1nnc(CCCO)n1-c1ccc(Cl)c(Cl)c1Cl |(26.4,-24.74,;25.78,-26.15,;26.68,-27.4,;28.22,-27.4,;28.7,-28.86,;27.45,-29.77,;27.45,-31.31,;28.79,-32.08,;30.12,-31.31,;31.45,-32.08,;26.21,-28.86,;24.74,-29.34,;23.6,-28.31,;22.13,-28.78,;21.81,-30.29,;20.35,-30.77,;22.96,-31.32,;22.64,-32.83,;24.42,-30.84,;25.57,-31.87,)| | ||
| Structure | 
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