| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase D |
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| Ligand | BDBM50516098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1863252 (CHEMBL4364108) |
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| IC50 | 735±n/a nM |
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| Citation |  Grädler, U; Schwarz, D; Blaesse, M; Leuthner, B; Johnson, TL; Bernard, F; Jiang, X; Marx, A; Gilardone, M; Lemoine, H; Roche, D; Jorand-Lebrun, C Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase D |
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| Name: | Peptidyl-prolyl cis-trans isomerase D |
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| Synonyms: | 40 kDa peptidyl-prolyl cis-trans isomerase | CYP-40 | CYP40 | CYPD | Cyclophilin D (CypD) | Cyclophilin-40 | Cyclophilin-related protein | PPID | PPID_HUMAN | PPIase D | Peptidyl-prolyl cis-trans isomerase D | Rotamase D |
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| Type: | Protein |
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| Mol. Mass.: | 40766.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08752 |
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| Residue: | 370 |
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| Sequence: | MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGH
TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSM
ANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAE
CGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWE
MAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEAL
ELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDK
EKAVYAKMFA
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| BDBM50516098 |
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| n/a |
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| Name | BDBM50516098 |
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| Synonyms: | CHEMBL4547673 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N3O5 |
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| Mol. Mass. | 425.4776 |
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| SMILES | [H][C@]12CC[C@]([H])(C1)[C@]1([H])C(=O)N(CC(=O)NCc3ccc4N[C@]5([H])C[C@@]([H])(OC[C@H]5O)c4c3)C(=O)[C@]21[H] |r| |
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| Structure | 
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