| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50071907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_148191 |
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| IC50 | 35±n/a nM |
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| Citation |  de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Pyrroles and other heterocycles as inhibitors of p38 kinase. Bioorg Med Chem Lett8:2689-94 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | Csbp1 | Csbp2 | MAP kinase p38 alpha | MK14_RAT | Mapk14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41315.23 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_148191 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50071907 |
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| n/a |
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| Name | BDBM50071907 |
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| Synonyms: | 2-(4-Chloro-phenyl)-4-(4-fluoro-phenyl)-5-pyridin-4-yl-1,2-dihydro-pyrazol-3-one | CHEMBL91730 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13ClFN3O |
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| Mol. Mass. | 365.788 |
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| SMILES | Fc1ccc(cc1)-c1c([nH]n(-c2ccc(Cl)cc2)c1=O)-c1ccncc1 |
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| Structure | 
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