| Reaction Details |
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 | Report a problem with these data |
| Target | Spindlin-1 |
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| Ligand | BDBM50353128 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875896 (CHEMBL4377290) |
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| IC50 | 3200±n/a nM |
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| Citation |  Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Bacher, J; Park, KS; Babault, N; Martini, M; Fagan, V; Li, F; Chau, I; Christott, T; Dilworth, D; Barsyte-Lovejoy, D; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem62:8996-9007 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Spindlin-1 |
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| Name: | Spindlin-1 |
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| Synonyms: | OCR | Ovarian cancer-related protein | SPIN | SPIN1 | SPIN1_HUMAN | Spindlin-1 | Spindlin1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29602.24 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119259 |
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| Residue: | 262 |
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| Sequence: | MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQH
GWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVAT
SRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQ
LLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKP
SVYFIKFDDDFHIYVYDLVKTS
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| BDBM50353128 |
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| n/a |
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| Name | BDBM50353128 |
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| Synonyms: | CHEMBL1231795 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H47N5O2 |
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| Mol. Mass. | 509.7265 |
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| SMILES | COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)C1CCCCC1 |
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| Structure | 
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