| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Spindlin-1 |
|---|
| Ligand | BDBM50519513 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1875896 (CHEMBL4377290) |
|---|
| IC50 | 338±n/a nM |
|---|
| Citation |  Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Bacher, J; Park, KS; Babault, N; Martini, M; Fagan, V; Li, F; Chau, I; Christott, T; Dilworth, D; Barsyte-Lovejoy, D; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem62:8996-9007 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Spindlin-1 |
|---|
| Name: | Spindlin-1 |
|---|
| Synonyms: | OCR | Ovarian cancer-related protein | SPIN | SPIN1 | SPIN1_HUMAN | Spindlin-1 | Spindlin1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 29602.24 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_119259 |
|---|
| Residue: | 262 |
|---|
| Sequence: | MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQH
GWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVAT
SRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQ
LLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKP
SVYFIKFDDDFHIYVYDLVKTS
|
|
|
|---|
| BDBM50519513 |
|---|
| n/a |
|---|
| Name | BDBM50519513 |
|---|
| Synonyms: | CHEMBL4588285 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H27N3O2 |
|---|
| Mol. Mass. | 293.4045 |
|---|
| SMILES | COc1c(CN)cc(CN)cc1OCCCN1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
