| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50074632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_86897 (CHEMBL698407) |
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| Ki | 5.3±n/a nM |
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| Citation |  Ali, SM; Tedford, CE; Gregory, R; Handley, MK; Yates, SL; Hirth, WW; Phillips, JG Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists. J Med Chem42:903-9 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50074632 |
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| n/a |
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| Name | BDBM50074632 |
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| Synonyms: | 4-((1S,2S)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl)-1H-imidazole | 4-[(1S,2S)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imidazole | CHEMBL354374 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N2 |
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| Mol. Mass. | 216.322 |
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| SMILES | CC(C)(C)CCC#C[C@H]1C[C@@H]1c1cnc[nH]1 |r| |
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| Structure | 
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