Found 56 hits with Last Name = 'tedford' and Initial = 'ce' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074629
(4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...)Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22541
(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12| Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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PC cid PC sid UniChem
Patents
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| Article
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin... |
Bioorg Med Chem Lett 7: 3017-3022 (1997)
Article DOI: 10.1016/S0960-894X(97)10137-8 BindingDB Entry DOI: 10.7270/Q2280843 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22541
(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12| Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22916
(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)Show InChI InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin... |
Bioorg Med Chem Lett 7: 3017-3022 (1997)
Article DOI: 10.1016/S0960-894X(97)10137-8 BindingDB Entry DOI: 10.7270/Q2280843 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074627
(4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...)Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070217
(3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-...)Show InChI InChI=1S/C15H17BrN4O3/c1-23-14-3-2-10(6-12(14)16)7-13(20-22)15(21)18-5-4-11-8-17-9-19-11/h2-3,6,8-9,13H,4-5,7H2,1H3,(H,17,19)(H,18,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070214
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070214
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM50070214
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070220
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070220
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM50070220
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85407
(GT 2231)Show SMILES N[C@@H](CC1CCCCC1)C=CCCc1cnc[nH]1 |r,w:10.11| Show InChI InChI=1S/C15H25N3/c16-14(10-13-6-2-1-3-7-13)8-4-5-9-15-11-17-12-18-15/h4,8,11-14H,1-3,5-7,9-10,16H2,(H,17,18)/b8-4+/t14-/m1/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM7967
(1-methyl-5-(beta-aminoethyl)-imidazole | 2-(1-meth...)Show InChI InChI=1S/C6H11N3/c1-9-5-8-4-6(9)2-3-7/h4-5H,2-3,7H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074630
(4-[2-(4-Cyclopentyl-but-1-ynyl)-cyclopropyl]-1H-im...)Show InChI InChI=1S/C15H20N2/c1-2-6-12(5-1)7-3-4-8-13-9-14(13)15-10-16-11-17-15/h10-14H,1-3,5-7,9H2,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 2 |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074624
(4-[2-(4-Cyclohexyl-but-1-ynyl)-cyclopropyl]-1H-imi...)Show InChI InChI=1S/C16H22N2/c1-2-6-13(7-3-1)8-4-5-9-14-10-15(14)16-11-17-12-18-16/h11-15H,1-4,6-8,10H2,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech, Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 275: 598-604 (1995)
BindingDB Entry DOI: 10.7270/Q21G0JSP |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074628
(4-Undec-3-ynyl-1H-imidazole | CHEMBL170723)Show InChI InChI=1S/C14H22N2/c1-2-3-4-5-6-7-8-9-10-11-14-12-15-13-16-14/h12-13H,2-7,10-11H2,1H3,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM50070211
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070211
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070211
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM85405
(GT 2227 | GT 2228)Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85412
(GT 2287)Show InChI InChI=1S/C16H24N2/c1(3-8-12-16-13-17-14-18-16)2-5-9-15-10-6-4-7-11-15/h13-15H,2,4-12H2,(H,17,18) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070216
(4-(8-Phenyl-oct-3-ynyl)-1H-imidazole | CHEMBL14811)Show InChI InChI=1S/C17H20N2/c1(2-4-9-13-17-14-18-15-19-17)3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,1,3,6,9-10,13H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070216
(4-(8-Phenyl-oct-3-ynyl)-1H-imidazole | CHEMBL14811)Show InChI InChI=1S/C17H20N2/c1(2-4-9-13-17-14-18-15-19-17)3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,1,3,6,9-10,13H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070212
(4-(7-Methyl-oct-3-ynyl)-1H-imidazole | CHEMBL14497)Show InChI InChI=1S/C12H18N2/c1-11(2)7-5-3-4-6-8-12-9-13-10-14-12/h9-11H,5-8H2,1-2H3,(H,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070212
(4-(7-Methyl-oct-3-ynyl)-1H-imidazole | CHEMBL14497)Show InChI InChI=1S/C12H18N2/c1-11(2)7-5-3-4-6-8-12-9-13-10-14-12/h9-11H,5-8H2,1-2H3,(H,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85405
(GT 2227 | GT 2228)Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1- | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 1 |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
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| Article
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin... |
Bioorg Med Chem Lett 7: 3017-3022 (1997)
Article DOI: 10.1016/S0960-894X(97)10137-8 BindingDB Entry DOI: 10.7270/Q2280843 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074622
(4-(2-Pent-1-ynyl-cyclopropyl)-1H-imidazole | CHEMB...)Show InChI InChI=1S/C11H14N2/c1-2-3-4-5-9-6-10(9)11-7-12-8-13-11/h7-10H,2-3,6H2,1H3,(H,12,13) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074632
(4-((1S,2S)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl)-...)Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
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| Article PubMed
| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85402
(GT 2327)Show InChI InChI=1S/C15H18N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-3,5-6,9-10,12-13H,4,7-8,11H2,(H,16,17)/b2-1- | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074625
(4-Non-3-ynyl-1H-imidazole | CHEMBL169929)Show InChI InChI=1S/C12H18N2/c1-2-3-4-5-6-7-8-9-12-10-13-11-14-12/h10-11H,2-5,8-9H2,1H3,(H,13,14) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074623
(4-[2-(5-Methyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...)Show InChI InChI=1S/C13H18N2/c1-10(2)5-3-4-6-11-7-12(11)13-8-14-9-15-13/h8-12H,3,5,7H2,1-2H3,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070213
(3-(4-Chloro-benzyl)-5-[2-(1H-imidazol-4-yl)-ethyl]...)Show InChI InChI=1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)7-13-18-14(20-19-13)6-5-12-8-16-9-17-12/h1-4,8-9H,5-7H2,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85399
(GT 2148)Show InChI InChI=1S/C15H20N4O/c16-14(7-6-12-4-2-1-3-5-12)15(20)18-9-8-13-10-17-11-19-13/h1-5,10-11,14H,6-9,16H2,(H,17,19)(H,18,20)/t14-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85405
(GT 2227 | GT 2228)Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1- | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 15.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074631
(4-[2-(6-Phenyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...)Show InChI InChI=1S/C18H20N2/c1(4-8-15-9-5-3-6-10-15)2-7-11-16-12-17(16)18-13-19-14-20-18/h3,5-6,9-10,13-14,16-17H,1-2,4,8,12H2,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 15.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85411
(GT 2174)Show InChI InChI=1S/C15H25N3O/c19-15(17-10-9-14-11-16-12-18-14)8-4-7-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,16,18)(H,17,19) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070215
(4-Hept-3-ynyl-1H-imidazole | CHEMBL276804)Show InChI InChI=1S/C10H14N2/c1-2-3-4-5-6-7-10-8-11-9-12-10/h8-9H,2-3,6-7H2,1H3,(H,11,12) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070215
(4-Hept-3-ynyl-1H-imidazole | CHEMBL276804)Show InChI InChI=1S/C10H14N2/c1-2-3-4-5-6-7-10-8-11-9-12-10/h8-9H,2-3,6-7H2,1H3,(H,11,12) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85401
(GT 2140)Show InChI InChI=1S/C14H24N4O/c15-13(8-11-4-2-1-3-5-11)14(19)17-7-6-12-9-16-10-18-12/h9-11,13H,1-8,15H2,(H,16,18)(H,17,19)/t13-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM86490
(CAS_0 | CHEMBL14812 | GT 2016 | NSC_0)Show InChI InChI=1S/C19H31N3O/c23-19(9-5-4-8-16-6-2-1-3-7-16)22-12-10-17(11-13-22)18-14-20-15-21-18/h14-17H,1-13H2,(H,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM86490
(CAS_0 | CHEMBL14812 | GT 2016 | NSC_0)Show InChI InChI=1S/C19H31N3O/c23-19(9-5-4-8-16-6-2-1-3-7-16)22-12-10-17(11-13-22)18-14-20-15-21-18/h14-17H,1-13H2,(H,20,21) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL PC cid PC sid UniChem
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| Article
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin... |
Bioorg Med Chem Lett 7: 3017-3022 (1997)
Article DOI: 10.1016/S0960-894X(97)10137-8 BindingDB Entry DOI: 10.7270/Q2280843 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50074626
(4-But-3-ynyl-1H-imidazole | CHEMBL170104)Show InChI InChI=1S/C7H8N2/c1-2-3-4-7-5-8-6-9-7/h1,5-6H,3-4H2,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 66.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |
Hrh3 protein
(RAT) | BDBM85406
(GT 2321)Show InChI InChI=1S/C15H26N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,1-11H2,(H,16,17) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 289: 1151-9 (1999)
BindingDB Entry DOI: 10.7270/Q2BZ64KX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070219
(4-Hex-3-ynyl-1H-imidazole | CHEMBL14721)Show InChI InChI=1S/C9H12N2/c1-2-3-4-5-6-9-7-10-8-11-9/h7-8H,2,5-6H2,1H3,(H,10,11) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor |
Bioorg Med Chem Lett 8: 1133-8 (1999)
BindingDB Entry DOI: 10.7270/Q2GF0SPX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50070219
(4-Hex-3-ynyl-1H-imidazole | CHEMBL14721)Show InChI InChI=1S/C9H12N2/c1-2-3-4-5-6-9-7-10-8-11-9/h7-8H,2,5-6H2,1H3,(H,10,11) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gliatech Inc.
Curated by ChEMBL
| Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement. |
J Med Chem 42: 903-9 (1999)
Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D |
More data for this Ligand-Target Pair | |