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Compile Data Set for Download or QSAR

Found 175 hits with Last Name = 'gregory' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074629
PNG
(4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...)
Show SMILES CC(C)(C)CCC#C[C@@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22541
PNG
(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Show SMILES NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1 |w:11.12|
Show InChI InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
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0.180n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074627
PNG
(4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...)
Show SMILES CC(C)(C)CCC#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)
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0.330n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070217
PNG
(3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-...)
Show SMILES COc1ccc(CC(N=O)C(=O)NCCc2cnc[nH]2)cc1Br
Show InChI InChI=1S/C15H17BrN4O3/c1-23-14-3-2-10(6-12(14)16)7-13(20-22)15(21)18-5-4-11-8-17-9-19-11/h2-3,6,8-9,13H,4-5,7H2,1H3,(H,17,19)(H,18,21)
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0.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070214
PNG
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)
Show SMILES CC(C)(C)CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15)
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0.800n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070214
PNG
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)
Show SMILES CC(C)(C)CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15)
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0.800n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM50070214
PNG
(4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole | CHEMBL2...)
Show SMILES CC(C)(C)CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C13H20N2/c1-13(2,3)9-7-5-4-6-8-12-10-14-11-15-12/h10-11H,6-9H2,1-3H3,(H,14,15)
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0.830n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070220
PNG
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)
Show SMILES C(CC1CCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16)
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0.900n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070220
PNG
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)
Show SMILES C(CC1CCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16)
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0.950n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM50070220
PNG
(4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole | CHEMBL...)
Show SMILES C(CC1CCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C14H20N2/c1(3-7-13-8-5-6-9-13)2-4-10-14-11-15-12-16-14/h11-13H,3-10H2,(H,15,16)
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0.950n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM7967
PNG
(1-methyl-5-(beta-aminoethyl)-imidazole | 2-(1-meth...)
Show SMILES Cn1cncc1CCN
Show InChI InChI=1S/C6H11N3/c1-9-5-8-4-6(9)2-3-7/h4-5H,2-3,7H2,1H3
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1n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85407
PNG
(GT 2231)
Show SMILES N[C@@H](CC1CCCCC1)C=CCCc1cnc[nH]1 |r,w:10.11|
Show InChI InChI=1S/C15H25N3/c16-14(10-13-6-2-1-3-7-13)8-4-5-9-15-11-17-12-18-15/h4,8,11-14H,1-3,5-7,9-10,16H2,(H,17,18)/b8-4+/t14-/m1/s1
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1n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074630
PNG
(4-[2-(4-Cyclopentyl-but-1-ynyl)-cyclopropyl]-1H-im...)
Show SMILES C(CC1CCCC1)C#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C15H20N2/c1-2-6-12(5-1)7-3-4-8-13-9-14(13)15-10-16-11-17-15/h10-14H,1-3,5-7,9H2,(H,16,17)
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1.43n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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1.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 2


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074624
PNG
(4-[2-(4-Cyclohexyl-but-1-ynyl)-cyclopropyl]-1H-imi...)
Show SMILES C(CC1CCCCC1)C#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C16H22N2/c1-2-6-13(7-3-1)8-4-5-9-14-10-15(14)16-11-17-12-18-16/h11-15H,1-4,6-8,10H2,(H,17,18)
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1.80n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074628
PNG
(4-Undec-3-ynyl-1H-imidazole | CHEMBL170723)
Show SMILES CCCCCCCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C14H22N2/c1-2-3-4-5-6-7-8-9-10-11-14-12-15-13-16-14/h12-13H,2-7,10-11H2,1H3,(H,15,16)
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2.80n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070211
PNG
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)
Show SMILES C(CC1CCCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17)
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2.90n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM50070211
PNG
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)
Show SMILES C(CC1CCCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17)
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2.90n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070211
PNG
(4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL1...)
Show SMILES C(CC1CCCCC1)C#CCCc1cnc[nH]1
Show InChI InChI=1S/C15H22N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,3-11H2,(H,16,17)
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2.90n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM85405
PNG
(GT 2227 | GT 2228)
Show SMILES C(CC1CCCCC1)C=CCCc1cnc[nH]1 |w:9.10|
Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1-
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3.20n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85412
PNG
(GT 2287)
Show SMILES C(CC#CCCc1cnc[nH]1)CC1CCCCC1
Show InChI InChI=1S/C16H24N2/c1(3-8-12-16-13-17-14-18-16)2-5-9-15-10-6-4-7-11-15/h13-15H,2,4-12H2,(H,17,18)
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3.40n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070216
PNG
(4-(8-Phenyl-oct-3-ynyl)-1H-imidazole | CHEMBL14811)
Show SMILES C(CCc1ccccc1)CC#CCCc1cnc[nH]1
Show InChI InChI=1S/C17H20N2/c1(2-4-9-13-17-14-18-15-19-17)3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,1,3,6,9-10,13H2,(H,18,19)
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3.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070216
PNG
(4-(8-Phenyl-oct-3-ynyl)-1H-imidazole | CHEMBL14811)
Show SMILES C(CCc1ccccc1)CC#CCCc1cnc[nH]1
Show InChI InChI=1S/C17H20N2/c1(2-4-9-13-17-14-18-15-19-17)3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,1,3,6,9-10,13H2,(H,18,19)
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3.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070212
PNG
(4-(7-Methyl-oct-3-ynyl)-1H-imidazole | CHEMBL14497)
Show SMILES CC(C)CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C12H18N2/c1-11(2)7-5-3-4-6-8-12-9-13-10-14-12/h9-11H,5-8H2,1-2H3,(H,13,14)
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3.70n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070212
PNG
(4-(7-Methyl-oct-3-ynyl)-1H-imidazole | CHEMBL14497)
Show SMILES CC(C)CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C12H18N2/c1-11(2)7-5-3-4-6-8-12-9-13-10-14-12/h9-11H,5-8H2,1-2H3,(H,13,14)
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3.70n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85405
PNG
(GT 2227 | GT 2228)
Show SMILES C(CC1CCCCC1)C=CCCc1cnc[nH]1 |w:9.10|
Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1-
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4.20n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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4.30n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 1


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074622
PNG
(4-(2-Pent-1-ynyl-cyclopropyl)-1H-imidazole | CHEMB...)
Show SMILES CCCC#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C11H14N2/c1-2-3-4-5-9-6-10(9)11-7-12-8-13-11/h7-10H,2-3,6H2,1H3,(H,12,13)
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5.10n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074632
PNG
(4-((1S,2S)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl)-...)
Show SMILES CC(C)(C)CCC#C[C@H]1C[C@@H]1c1cnc[nH]1 |r|
Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85402
PNG
(GT 2327)
Show SMILES C(Cc1cnc[nH]1)C=CCCc1ccccc1 |w:7.7|
Show InChI InChI=1S/C15H18N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-3,5-6,9-10,12-13H,4,7-8,11H2,(H,16,17)/b2-1-
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5.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074625
PNG
(4-Non-3-ynyl-1H-imidazole | CHEMBL169929)
Show SMILES CCCCCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C12H18N2/c1-2-3-4-5-6-7-8-9-12-10-13-11-14-12/h10-11H,2-5,8-9H2,1H3,(H,13,14)
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5.60n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074623
PNG
(4-[2-(5-Methyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...)
Show SMILES CC(C)CCC#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C13H18N2/c1-10(2)5-3-4-6-11-7-12(11)13-8-14-9-15-13/h8-12H,3,5,7H2,1-2H3,(H,14,15)
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6.5n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070213
PNG
(3-(4-Chloro-benzyl)-5-[2-(1H-imidazol-4-yl)-ethyl]...)
Show SMILES Clc1ccc(Cc2noc(CCc3cnc[nH]3)n2)cc1
Show InChI InChI=1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)7-13-18-14(20-19-13)6-5-12-8-16-9-17-12/h1-4,8-9H,5-7H2,(H,16,17)
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7n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85399
PNG
(GT 2148)
Show SMILES N[C@@H](CCc1ccccc1)C(=O)NCCc1cnc[nH]1 |r|
Show InChI InChI=1S/C15H20N4O/c16-14(7-6-12-4-2-1-3-5-12)15(20)18-9-8-13-10-17-11-19-13/h1-5,10-11,14H,6-9,16H2,(H,17,19)(H,18,20)/t14-/m0/s1
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11n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85405
PNG
(GT 2227 | GT 2228)
Show SMILES C(CC1CCCCC1)C=CCCc1cnc[nH]1 |w:9.10|
Show InChI InChI=1S/C15H24N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h1-2,12-14H,3-11H2,(H,16,17)/b2-1-
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15.2n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074631
PNG
(4-[2-(6-Phenyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...)
Show SMILES C(CCc1ccccc1)CC#CC1CC1c1cnc[nH]1
Show InChI InChI=1S/C18H20N2/c1(4-8-15-9-5-3-6-10-15)2-7-11-16-12-17(16)18-13-19-14-20-18/h3,5-6,9-10,13-14,16-17H,1-2,4,8,12H2,(H,19,20)
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15.9n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85411
PNG
(GT 2174)
Show SMILES O=C(CCCC1CCCCC1)NCCc1cnc[nH]1
Show InChI InChI=1S/C15H25N3O/c19-15(17-10-9-14-11-16-12-18-14)8-4-7-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,16,18)(H,17,19)
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16n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070215
PNG
(4-Hept-3-ynyl-1H-imidazole | CHEMBL276804)
Show SMILES CCCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C10H14N2/c1-2-3-4-5-6-7-10-8-11-9-12-10/h8-9H,2-3,6-7H2,1H3,(H,11,12)
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27n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070215
PNG
(4-Hept-3-ynyl-1H-imidazole | CHEMBL276804)
Show SMILES CCCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C10H14N2/c1-2-3-4-5-6-7-10-8-11-9-12-10/h8-9H,2-3,6-7H2,1H3,(H,11,12)
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27n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85401
PNG
(GT 2140)
Show SMILES N[C@@H](CC1CCCCC1)C(=O)NCCc1cnc[nH]1 |r|
Show InChI InChI=1S/C14H24N4O/c15-13(8-11-4-2-1-3-5-11)14(19)17-7-6-12-9-16-10-18-12/h9-11,13H,1-8,15H2,(H,16,18)(H,17,19)/t13-/m0/s1
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31n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM86490
PNG
(CAS_0 | CHEMBL14812 | GT 2016 | NSC_0)
Show SMILES O=C(CCCCC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C19H31N3O/c23-19(9-5-4-8-16-6-2-1-3-7-16)22-12-10-17(11-13-22)18-14-20-15-21-18/h14-17H,1-13H2,(H,20,21)
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40n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50074626
PNG
(4-But-3-ynyl-1H-imidazole | CHEMBL170104)
Show SMILES C#CCCc1cnc[nH]1
Show InChI InChI=1S/C7H8N2/c1-2-3-4-7-5-8-6-9-7/h1,5-6H,3-4H2,(H,8,9)
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66.3n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85406
PNG
(GT 2321)
Show SMILES C(CCCc1cnc[nH]1)CCC1CCCCC1
Show InChI InChI=1S/C15H26N2/c1(2-7-11-15-12-16-13-17-15)4-8-14-9-5-3-6-10-14/h12-14H,1-11H2,(H,16,17)
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75n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070219
PNG
(4-Hex-3-ynyl-1H-imidazole | CHEMBL14721)
Show SMILES CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C9H12N2/c1-2-3-4-5-6-9-7-10-8-11-9/h7-8H,2,5-6H2,1H3,(H,10,11)
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79n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.


J Med Chem 42: 903-9 (1999)


Article DOI: 10.1021/jm980310g
BindingDB Entry DOI: 10.7270/Q2ST7P1D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50070219
PNG
(4-Hex-3-ynyl-1H-imidazole | CHEMBL14721)
Show SMILES CCC#CCCc1cnc[nH]1
Show InChI InChI=1S/C9H12N2/c1-2-3-4-5-6-9-7-10-8-11-9/h7-8H,2,5-6H2,1H3,(H,10,11)
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79n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor


Bioorg Med Chem Lett 8: 1133-8 (1999)


BindingDB Entry DOI: 10.7270/Q2GF0SPX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85403
PNG
(GT 2130)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)NCCc1cnc[nH]1 |r|
Show InChI InChI=1S/C14H18N4O/c15-13(8-11-4-2-1-3-5-11)14(19)17-7-6-12-9-16-10-18-12/h1-5,9-10,13H,6-8,15H2,(H,16,18)(H,17,19)/t13-/m0/s1
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104n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85404
PNG
(GT 2146)
Show SMILES N[C@H](C(=O)NCCc1cnc[nH]1)c1ccccc1 |r|
Show InChI InChI=1S/C13H16N4O/c14-12(10-4-2-1-3-5-10)13(18)16-7-6-11-8-15-9-17-11/h1-5,8-9,12H,6-7,14H2,(H,15,17)(H,16,18)/t12-/m0/s1
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630n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85408
PNG
(GT 2288)
Show SMILES C(CC#Cc1cnc[nH]1)CC1CCCCC1
Show InChI InChI=1S/C14H20N2/c1-3-7-13(8-4-1)9-5-2-6-10-14-11-15-12-16-14/h11-13H,1-5,7-9H2,(H,15,16)
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UniChem

Patents

PubMed
1.03E+3n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85409
PNG
(GT 2142)
Show SMILES CN[C@@H](Cc1ccccc1)C(=O)NCCc1cnc[nH]1 |r|
Show InChI InChI=1S/C15H20N4O/c1-16-14(9-12-5-3-2-4-6-12)15(20)18-8-7-13-10-17-11-19-13/h2-6,10-11,14,16H,7-9H2,1H3,(H,17,19)(H,18,20)/t14-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

PubMed
1.59E+3n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
Hrh3 protein


(RAT)
BDBM85400
PNG
(GT 2136)
Show SMILES N[C@H](Cc1ccccc1)C(=O)NCCc1cnc[nH]1 |r|
Show InChI InChI=1S/C14H18N4O/c15-13(8-11-4-2-1-3-5-11)14(19)17-7-6-12-9-16-10-18-12/h1-5,9-10,13H,6-8,15H2,(H,16,18)(H,17,19)/t13-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

PubMed
2.81E+3n/an/an/an/an/an/an/an/a



Gliatech Inc.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 1151-9 (1999)


BindingDB Entry DOI: 10.7270/Q2BZ64KX
More data for this
Ligand-Target Pair
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